Path of Exile Top 7 Sanctum Builds
1. Penance Brand of Dissipation Inquisitor (Templar)
The Penance Brand of Dissipation Inquisitor is one of the best single target builds and does well with clearing damage.
Mapping: 10/10 Delve: 9/10 Heist: 10/10 Damage: 10/10 Safety: 8/10 Bosses: 10/10

Build Guide
This build excels at single target and as an added bonus it has excellent mobility which makes this build phenomenal for the Forbidden Sanctum. You only need to cast two Penance Brands on bosses and tough enemies and then you are free to move around and dodge mechanics. If you are interested in trying out the Penance Brand of Dissipation Inquisitor for the Forbidden Sanctum you can find a guide for the build here Penance Brand of Dissipation Inquisitor Guide.
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2. Mirror Arrow & Blink Arrow Necromancer (Witch)
The Poison Mirror Arrow & Blink Arrow Summoner was slightly nerfed back in 3.27 and comes in at second place.
Mapping: 9/10 Delve: 10/10 Heist: 8/10 Damage: 9/10 Safety: 10/10 Bosses: 9/10

Build Guide
The Mirror Arrow of Bombarding Clones and Blink Arrow of Prismatic Clones Summoner Necromancer is a minion build that can teleport which makes it excellent in the Forbidden Sanctum. The build has high single target damage while still maintaining very strong clearing damage. If you're interested in trying out the Mirror Arrow & Blink Arrow Summoner Necromancer you can find a guide for the build here Mirror Arrow and Blink Arrow Necromancer Guide.
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3. Siege Ballista Hierophant (Templar)
Siege Ballista Hierophants are greatly improved by their dexterity which allows for very high damage with excellent gear.
Mapping: 10/10 Delve: 9/10 Heist: 8/10 Damage: 10/10 Safety: 9/10 Bosses: 9/10

Build Guide
The Siege Ballista Hierophant has excellent damage potential in the Forbidden Sanctum and enemies will typically attack your numerous totems which can also taunt enemies. This build is a dexterity stacking build with a very high damage ceiling that increases in damage and gains more totems with increased dexterity. If you're interested in trying out the Siege Ballista Hierophant build you can find a guide for it here Dexterity Stacking Siege Ballista Hierophant Guide.
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4. Explosive Arrow Totem Elementalist (Witch)
The Explosive Arrow Totem Elementalist has very strong single target damage and is excellent in the Forbidden Sanctum.
Mapping: 10/10 Delve: 7/10 Heist: 9/10 Damage: 9/10 Safety: 8/10 Bosses: 10/10

Build Guide
The Explosive Arrow Totem Elementalist is one of the strongest builds for the Forbidden Sanctum because it's a totem build with great mobility and high single target damage. You will also have plenty of ballista totems that can taunt your enemies and your totems will typically take the damage for you. If you're interested in trying out the Explosive Arrow Ballista Totem Elementalist you can find a guide for the build here Explosive Arrow Totem Elementalist Guide.
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5. Poison Summon Raging Spirits Necromancer (Witch)
This build is considered the one of the strongest minion builds with up to twenty Raging Spirits that seek out enemies.
Mapping: 10/10 Delve: 10/10 Heist: 10/10 Damage: 10/10 Safety: 10/10 Bosses: 10/10

Build Guide
The Poison Summon Raging Spirit Necromancer also known as the Poison SRS Necromancer is considered the strongest minion build in the game and excels at the Forbidden Sanctum. It's single target damage is extremely impressive while still maintaining excellent damage against large groups of enemies. If you're interested in trying out the Poison Summon Raging Spirit Necromancer build you can find a guide for it here Summon Raging Spirit Necromancer Guide.
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6. Freezing Pulse Totem Hierophant (Templar)
The Freezing Pulse Totem Hierophant is the strongest spell totem build in the game with a freezing attack.
Mapping: 10/10 Delve: 10/10 Heist: 10/10 Damage: 9/10 Safety: 10/10 Bosses: 8/10

Build Guide
The Freezing Pulse Totem Hierophant is the best spell totem build in the game for the Forbidden Sanctum and has a freezing and chilling attack that helps keep your resolve high. With this totem build you will only need to cast a few totems nearby your enemies and then you're free to dodge mechanics. If you're interested in trying out the Freezing Pulse Totem Hierophant build you can find a guide for it here Freezing Pulse Totem Hierophant Guide.
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7. Golem Summoner Elementalist (Witch)
The Golem Summoner Elementalist is excellent at the Forbidden Sanctum and is one of the best builds for survival.
Mapping: 9/10 Delve: 10/10 Heist: 9/10 Damage: 9/10 Safety: 9/10 Bosses: 10/10

Build Guide
The Golem Elementalist is a top tier build for the Forbidden Sanctum in part because Carrion Golems attack while you're moving and in part because Carrion Golems are naturally aggressive. You will also have an army of minions to take the damage for you and an elemental shield that absorbs elemental damage. If you're interested in trying out the Carrion Golem Elementalist build in the Forbidden Sanctum you can find a guide for it here Carrion Golem Elementalist Guide.
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HM. Vaal Skeleton of Mages Summoner Necromancer
The Mage Skeleton Summoner Necromancer is one of the best minion builds in the game for surviving difficult fights.
Mapping: 10/10 Delve: 8/10 Heist: 8/10 Damage: 9/10 Safety: 8/10 Bosses: 10/10

Build Guide
The Skeleton of Mages Necromancer is very strong in the Forbidden Sanctum as a ranged minion build that deals damage from a distance. Skeleton mages cast spells at far away enemies which helps keeps your resolve high and your skeleton mages can also ignore the elemental resistances of enemies. If you would like to try out the Skeleton Mage Summoner Necromancer build a guide for it can be found here Vaal Skeleton of Mages Summoner Necromancer Guide.​
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That's all for the Top 7 Sanctum Builds! For more on PoE Sanctum you can view an endgame guide here Endgame Guide.
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